Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome J Biol Chem. 2016
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. J Biol Chem. 2016
Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Nat Acad of Sci. 2015.
The signaling phospholipid PIP3 binds SF-1 creating a new interaction surface at the entrance of the ligand binding pocket. Proc Nat Acad of Sci. 2014.
Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family. Proteins 2014.
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme. J Biol Chem. 2013.
Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling. J Bacteriol. 2013
Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum. Acta Crystallogr D Biol Crystallogr. 2012.
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature 2011.
Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein PLoS One 2011.
Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair. J Mol Biol. 2011.
July 2020: Accelero Biostructures Partners with Mid-Atlantic BioTherapeutics to develop Pan-Coronavirus Inhibitors; Receives NIH Funding to Support the Research
May 2019: Accelero Biostructures, Inc. has received additional non-dilutive funding from the National Institutes of Health (NIH) under the Small Business Innovation Research (SBIR) Phase II program
March 2019: Accelero Biostructures, Inc. expedites structure determinations for groundbreaking research expanding the DNA alphabet from 4 to 8 building blocks
Sept. 2016: Accelero Biostructures, Inc. has received non-dilutive funding from the National Institutes of Health (NIH) under the Small Business Innovation Research (SBIR) Phase I program
January 2015: Accelero Biostructures, Inc. is founded with help from the University of California’s QB3 program
