Media Releases:
San Francisco: September 2016
“Accelero Biostructures, Inc., has received non-dilutive funding from the National Institutes of Health (NIH) under the Small Business Innovation Research (SBIR) program. Accelero Biostructures develops technologies and tools for accelerating structure-based drug discovery and protein engineering using its deep expertise in high-throughput protein x-ray crystallography.”
Read More / DownloadSan Francisco: January 2015
Accelero Biostructures is founded with help from the University of California’s QB3 program
Read More / DownloadPublications:
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.
J Biol Chem. 2016
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.
J Biol Chem. 2016
Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.
J Struct Biol. 2015
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proc Nat Acad of Sci. 2015
Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family.
Proteins 2014
The signaling phospholipid PIP3 binds SF-1 creating a new interaction surface at the entrance of the ligand binding pocket
Proc Nat Acad of Sci. 2014
Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis
BMC Bioinformatics. 2014
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.
J Biol Chem. 2013
Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.
J Bacteriol. 2013
Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum.
Acta Crystallogr D Biol Crystallogr. 2012
Improved molecular replacement by density- and energy-guided protein structure optimization.
Nature 2011